Chronic cough treatment discovery

A MEDICATION designed for pain and epilepsy has potential benefits for sufferers of often-untreatable chronic cough, a Hunter study has found.
Nanjing Night Net

The results are published today in the international journal The Lancet.

Clinical research scientist and study leader Nicole Ryan said the condition, known as refractory chronic cough, lasted eight weeks or more.

It could be debilitating and patients often did not respond to treatment, she said.

University of Newcastle and Hunter Medical Research Institute specialists worked with 62 patients, who were given drug Gabapentin, or a placebo, for 10 weeks.

Three-quarters of patients in the Gabapentin group reported a sustained improvement in cough severity, frequency and quality of life, compared with fewer than half of the placebo group.

Side effects, including dizziness, fatigue and nausea, occurred in 10 patients given Gabapentin and three taking the placebo. The drug’s efficacy was not sustained after treatment stopped.

Study participant Jan Douglas, 57, had a chronic cough for about seven years, and struggled with simple tasks such as telephone calls.

Mrs Douglas said that after taking the drug, the amount of coughing decreased considerably.

Her quality of life has improved and the Medowie resident was boarding a plane as she spoke to the Newcastle Herald by phone yesterday.

The Hunter researchers are now studying another drug as a potential chronic cough treatment, which has fewer side effects and is expected to be more effective at a lower dose.

RESPONSE: Nicole Ryan led a study on chronic cough in which a medication designed for epilepsy had potential benefits.

Posted by at 22/05/2018
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